1,1'-Carbonyldiimidazole → (S)-N-[5-(4-Methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methylpyridine-3-carboxamide

HRID 131132

反応式

HRID 131132 の反応式
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[NH2:23][C@H:24]1[CH2:29][C:28]2[C:30]([N:34]3[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]3)=[CH:31][CH:32]=[CH:33][C:27]=2[O:26][CH2:25]1>CN(C)C=O>[CH3:40][N:37]1[CH2:38][CH2:39][N:34]([C:30]2[C:28]3[CH2:29][C@H:24]([NH:23][C:7]([C:6]4[CH:5]=[N:4][CH:3]=[C:2]([CH3:1])[CH:10]=4)=[O:9])[CH2:25][O:26][C:27]=3[CH:33]=[CH:32][CH:31]=2)[CH2:35][CH2:36]1

参加物

5

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 2562085-Methylnicotinic acidHCID 11139461(S)-3-amino-5-(4-methylpiperazin-1-yl)-1,4-dihydro-2H-1-benzopyran

生成物 1

HCID 69207425(S)-N-[5-(4-Methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methylpyridine-3-carboxamide収率 35%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

A solution of 5-methylnicotinic acid (141 mg, 1.03 mmol) and 1,1′-carbonyldiimidazole (183 mg, 1.13 mmol) in anhydrous N,N-dimethylformamide (5 mL) was stirred at 75° C. for 55 min. The mixture was allowed to cool, and a solution of (S)-3-amino-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran (232 mg, 0.94 mmol) in N,N-dimethylformamide (5 mL) was added. The reaction mixture was stirred at room temperature for 28 h. The solvent was removed in vacuo, and the residue was purified by column chromatography on silica (eluent: chloroform/ethanol; 87:13+0.5% NH3). The product was contaminated with a large amount of imidazole which could be removed by the following procedure: The mixture was dissolved in diethyl ether (100 mL), washed with water (2+20 mL) and treated with brine (10 mL). The ethereal layer was dried (MgSO4), and the solvent was removed in vacuo to give 119 mg (35% yield) of the title compound as a white solid: mp sinters >68° C.; [α]21D −82° (c 1.0, chloroform); EIMS (70 eV) m/z (relative intensity) 366 (21, M+).

後処理

  1. temperatureto cool
  2. customThe solvent was removed in vacuo
  3. customthe residue was purified by column chromatography on silica (eluent: chloroform/ethanol; 87:13+0.5% NH3)
  4. customcould be removed by the following procedure
  5. dissolutionThe mixture was dissolved in diethyl ether (100 mL)
  6. washwashed with water (2+20 mL)
  7. additiontreated with brine (10 mL)
  8. dry with materialThe ethereal layer was dried (MgSO4)
  9. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-c3002aa0348742e5a93313e77a962113
出典データセット
uspto-grants-2008_06
特許番号
US07384943B2

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