Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

反応式

C1COCCN1.FC(F)(F)c1ccc(Br)cc1>F[B-](F)(F)F.c1c[n+](C23CC4CC(CC(C4)C2)C3)cn1C12CC3CC(CC(C3)C1)C2.C[Si](C)(C)[N-][Si](C)(C)C.[Na+].COCCOCCOC.COCCOCCOC.COCCOCCOC.COCCOCCOC.COCCOCCOC>Cn1c(=O)c2c(ncn2C)n(C)c1=O.FC(F)(F)c1ccc(N2CCOCC2)cc1.FC(F)(F)c1cccc(N2CCOCC2)c1

参加物

反応条件

温度: 60 °C

後処理

customThe foil sealing tape was removed from the plate.
addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 相を保持
aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

出典と根拠

ORDレコード: ord-9a1afcc4876d4c83aa4a6c8a7d85ede4
出典データセット: High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
DOI: 10.1021/jacs.6c05959
元リンク: 出典を表示

反応ノート

読み込み中…

参加物

反応物 2

HCID 8083Morpholine

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

生成物 3

HCID 2519Caffeine

HCID 109333104-(4-Trifluoromethylphenyl)morpholine収率 24.039%

HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine収率 19.293%

試薬・触媒・溶媒 3

HCID 2724254Sodium bis(trimethylsilyl)amide試薬

HCID 162181051,3-Bis(1-adamantyl)imidazolium tetrafluoroborate触媒

HCID 8150Diglyme溶媒5 回

反応条件

温度: 60 °C

後処理

customThe foil sealing tape was removed from the plate.
addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 相を保持
aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

出典と根拠

ORDレコード: ord-9a1afcc4876d4c83aa4a6c8a7d85ede4
出典データセット: High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
DOI: 10.1021/jacs.6c05959
元リンク: 出典を表示

反応ノート

読み込み中…