2-[(Benzylmethylamino)methyl]-1-pyridin-3-ylcyclohexanol hydrochloride → 2-Methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochloride

HRID 131526ノート

反応式

HRID 131526 の反応式
[ClH:1].C([CH2:9][NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[OH:18])C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]>[ClH:1].[CH3:9][NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[OH:18]

参加物

5

反応物 2

HCID 692216432-[(Benzylmethylamino)methyl]-1-pyridin-3-ylcyclohexanol hydrochlorideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 692224012-Methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochloride収率 75.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

11.1 g 2-[(benzylmethylamino)methyl]-1-pyridin-3-yl-cyclohexanol hydrochloride were dissolved in 110 ml glacial acetic acid under nitrogen, 2.0 g palladium-on-active charcoal (10 percent by weight) were added as a catalyst and the mixture was stirred under a hydrogen pressure of 2.0 bar until the uptake of hydrogen had ended. The mixture was filtered with suction, the filtrate was concentrated, the residue was stirred overnight with 75 ml isopropanol and the precipitate obtained was filtered off with suction and dried. 6.18 g 2-methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochloride were obtained.

後処理

  1. filtrationThe mixture was filtered with suction
  2. concentrationthe filtrate was concentrated
  3. customthe precipitate obtained
  4. filtrationwas filtered off with suction
  5. customdried

出典と根拠

ORDレコード
ord-8402a9c933c44beea814ede68bde611e
出典データセット
uspto-grants-2008_06
特許番号
US07384961B2

反応ノート

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