Water → 6-Chloro-3-methyl-1-propyl-2,4(1H,3H)-pyrimidinedione

HRID 131571

反応式

HRID 131571 の反応式
[Cl:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:17](I)[CH2:18][CH3:19].O>CN(C=O)C>[Cl:1][C:2]1[N:7]([CH2:17][CH2:18][CH3:19])[C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 961416-chloro-3-methylpyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 8169336-Chloro-3-methyl-1-propyl-2,4(1H,3H)-pyrimidinedione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6-chloro-3-methyl uracil (10 g) and potassium carbonate (10.34 g) in DMF (70 ml) under nitrogen was treated with n-propyl iodide (25.4 g) and heated at reflux for 8 h. The reaction 30 was cooled and then poured into water (700 ml) and extracted with ethyl acetate. The combined organics were dried and evaporated in vacuo to afford the subtitle compound an orange oil, 17.52 g. δ 1HCDCl3 0.98 (3H, t), 1.74 (2H, sextet), 3.33 (3H, s), 4.02 (2H, t), 8.02 (1H, s).

後処理

  1. temperatureheated
  2. temperatureat reflux for 8 h
  3. customThe reaction 30
  4. temperaturewas cooled
  5. extractionextracted with ethyl acetate
  6. customThe combined organics were dried
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-123c4983d1f349798e70b6e416ec6dbf
出典データセット
uspto-grants-2008_06
特許番号
US07384950B2

関連ノート

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