N-(2-Methoxy-5-nitrobenzyl)acetamide → HCID 58629454、化合物

HRID 131667ノート

反応式

HRID 131667 の反応式
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][C:4]=1[CH2:5][NH:6][C:7](=[O:9])[CH3:8].[H][H]>[Pd].C(O)C>[C:7]([NH:6][CH2:5][C:4]1[CH:10]=[C:11]([CH:12]=[CH:13][C:3]=1[O:2][CH3:1])[NH2:14])(=[O:9])[CH3:8]

参加物

5

反応物 2

HCID 20650534N-(2-Methoxy-5-nitrobenzyl)acetamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 58629454HCID 58629454、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

N-(2-Methoxy-5-nitrobenzyl)acetamide (5 g), with palladium on carbon (1 g) in ethanol (50 ml) was hydrogenated at room temperature under 104 tms. of hydrogen. The reaction was filtered through celite and the ethanol distilled from the filtrate. The residue was recrystallised from benzene to give 3-(acetylaminomethyl)-4-methoxyaniline as pale brown needles. MP; 123-125° C.

後処理

  1. customwas hydrogenated at room temperature under 104 tms
  2. filtrationThe reaction was filtered through celite
  3. distillationthe ethanol distilled from the filtrate
  4. customThe residue was recrystallised from benzene

出典と根拠

ORDレコード
ord-2ef501d97cf64e05a715175de250eed0
出典データセット
uspto-grants-2008_06
特許番号
US07384963B2

反応ノート

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