化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | methyl 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetate | HCID 59339649 | — |
| 生成物 | 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetamide | HCID 59339722 | — |
反応手順
A suspension of methyl 2-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-2-phenylacetate (137c, 75 mg, 200 μmol) in methanolic NH3 (7 M, 1 ml) was stirred at r.t. overnight to give a clear solution. Then the solvent was removed in vacuo, and the crude product was freeze-dried go give white solid material, 60 mg (83%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728030B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-81d60e2148214d4e864b058f4eaadea7 |
| 出典メモ | uspto-grants-2010_06 |