Methylhydroquinone → 4-Hydroxy-3-methylphenyl acetate
反応式
[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].[OH:8][C:9]1[CH:14]=[CH:13]C(O)=[C:11](C)[CH:10]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[C:5]([O:4][C:1]1[CH:11]=[CH:10][C:9]([OH:8])=[C:14]([CH3:13])[CH:2]=1)(=[O:7])[CH3:6]参加物
5
実験手順
Acetic anhydride (4.73 gm, 4.37 mL, 46.3 mMol) was added dropwise to a mixture of 4-hydroxy-2-methylphenol (5 gm, 46.3 mMol) and cesium carbonate (15.1 gm, 46.3 mMol) in acetonitrile (50 mL). After stirring overnight, the mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel chromatography, eluting with 5:1 pentane:ethyl acetate. Fractions containing product were combined and concentrated under reduced pressure to provide 0.24 gm (3%) of the desired compound.
後処理
- filtrationthe mixture was filtered
- concentrationthe filtrate was concentrated under reduced pressure
- washeluting with 5:1 pentane
- additionFractions containing product
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-9791b4f6a2c1460ebe7e3ef50b834101
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07384983B2
反応ノート
読み込み中…