Triphenylphosphine → tert-Butyl 4-[(1R)-3-chloro-1-phenylpropoxy]-3-methylphenyl carbonate

温度

0 °C

An oven dried, three-necked, 2-L, round-bottomed flask was charged with (S)-3-chloro-1-phenyl-propanol (52 g, 304 mmol), 4-((tert-butoxycarbonyl)oxy)-2-methylphenol (73.86 g, 329 mmol), triphenylphosphine (87.36 g, 333 mmol) and anhydrous tetrahydrofuran (600 ml). The reaction mixture was cooled at 0° C., and a solution of diisopropylazadicarbox-ylate (76 ml, 365 mmol,) in dry tetrahydrofuran (100 mL) was added over 6 hours. The reaction mixture was stirred for an additional two hours at 0° C. and was then allowed to warm gradually to room temperature. The reaction mixture was further stirred at room temperature for 24 hours and the reaction mixture was concentrated under reduced pressure. The residue was treated with 2 L of 9:1 pentane:ethyl acetate. The resulting suspension was stored at −20° C. for 24 hours and the insoluble materials were removed by filtration. The precipitate was washed with 9:1 pentane:ethyl acetate (200 mL). The combined filtrates were concentrated under reduced pressure. The crude residue (150 grams) was purified by 150 flash Biotage pre-packed column eluting with 3% ethyl acetate in hexane to provide (R)-3-chloro-1-phenyl-1-(2-methyl-4-((tert-butoxycarbonyl)oxy)-phenoxy)propane (100 g) in 85% yield.

1. customAn oven dried
2. temperatureto warm gradually to room temperature
3. stirringThe reaction mixture was further stirred at room temperature for 24 hours
4. concentrationthe reaction mixture was concentrated under reduced pressure
5. additionThe residue was treated with 2 L of 9:1 pentane
6. waitThe resulting suspension was stored at −20° C. for 24 hours
7. customthe insoluble materials were removed by filtration
8. washThe precipitate was washed with 9:1 pentane
9. concentrationThe combined filtrates were concentrated under reduced pressure
10. customThe crude residue (150 grams) was purified by 150 flash Biotage pre-packed column
11. washeluting with 3% ethyl acetate in hexane

ORDレコード

ord-c0b2312fa6d44e5d9f96007ea488fe43

出典データセット

uspto-grants-2008_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07384983B2