化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(4-Isopropylphenoxy)-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 4-Isopropylphenol | HCID 7465 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-(4-Isopropylphenoxy)aniline | HCID 26189126 | — |
| 生成物 | N-[2-(4-Isopropylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732791 | 70% |
| 生成物 | 2-(4-Isopropylphenoxy)-1-nitrobenzene | HCID 66998970 | 75% |
反応手順
2-(4-Isopropylphenoxy)-1-nitrobenzene (0.95 g, 75%) was prepared from 4-isopropylphenol (0.68 g, 5.0 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(4-isopropylphenoxy)aniline (0.34 g, 60%, 2.5 mmol scale) following general procedure B. N-[2-(4-Isopropylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (247 mg, 70%) was prepared from 2-(4-isopropylphenoxy)aniline (227 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07384967B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-1266839af7aa426e875d08c1f783666d |
| 出典メモ | uspto-grants-2008_06 |