HRID131793

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2155

2-Aminothiazole

C3H4N2S

HCID7465

4-Isopropylphenol

C9H12O

HCID73895

Benzene, 1-fluoro-2-nitro-

C6H4FNO2

HCID26189126

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)c1ccc(Oc2ccccc2NC(=O)Nc2nccs2)cc1

HCID59732791

未命名化合物

收率 70%

HCID66998970

未命名化合物

收率 75%

PROCEDURE

实验过程

2-(4-Isopropylphenoxy)-1-nitrobenzene (0.95 g, 75%) was prepared from 4-isopropylphenol (0.68 g, 5.0 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(4-isopropylphenoxy)aniline (0.34 g, 60%, 2.5 mmol scale) following general procedure B. N-[2-(4-Isopropylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (247 mg, 70%) was prepared from 2-(4-isopropylphenoxy)aniline (227 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1266839af7aa426e875d08c1f783666d
来源数据集: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07384967B2
来源说明: uspto-grants-2008_06

反应 SMILES

[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].F[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N+:18]([O-:20])=[O:19].[CH:21]([C:24]1[CH:37]=[CH:36][C:27]([O:28][C:29]2[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=2[NH2:31])=[CH:26][CH:25]=1)([CH3:23])[CH3:22].[NH2:38][C:39]1[S:40][CH:41]=[CH:42][N:43]=1>>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-:20])=[O:19])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH:21]([C:24]1[CH:37]=[CH:36][C:27]([O:28][C:29]2[CH:35]=[CH:34][CH:33]=[CH:32][C:30]=2[NH:31][C:7]([NH:38][C:39]2[S:40][CH:41]=[CH:42][N:43]=2)=[O:10])=[CH:26][CH:25]=1)([CH3:23])[CH3:22]