2-Aminothiazole → Benzene, 1-fluoro-2-[(2-nitrophenyl)thio]-

HRID 131844

反応式

HRID 131844 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].F[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17].[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[S:26][C:27]1[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=1[NH2:29].[NH2:34][C:35]1SC=[CH:38][N:39]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-:18])=[O:17].[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[S:26][C:27]1[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=1[NH:29][C:38]([NH:39][C:35]1[S:8][CH:3]=[CH:2][N:34]=1)=[O:17]

参加物

6

反応物 4

HCID 21552-AminothiazoleHCID 738951-Fluoro-2-nitrobenzeneHCID 5202162-FluorothiophenolHCID 118503572-(2-Fluorophenylsulfanyl)aniline2 回

生成物 2

HCID 11850287Benzene, 1-fluoro-2-[(2-nitrophenyl)thio]-収率 83%HCID 59733001HCID 59733001、化合物収率 75%

実験手順

2-(2-Fluorophenylsulfanyl)nitrobenzene (1.03 g, 83%) was prepared from 2-fluorothiophenol (0.70 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2-fluorophenylsulfanyl)aniline (0.65 g, 72%) following general procedure B. N-[2-(2-Fluorophenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (129 mg, 75%) was prepared from 2-(2-fluorophenylsulfanyl)aniline (107 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

出典と根拠

ORDレコード
ord-782ed4d5a4c34964901422f06cd6ca0d
出典データセット
uspto-grants-2008_06
特許番号
US07384967B2

関連ノート

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