2-Methyl-3-nitroaniline → 4-Iodo-2-methyl-3-nitrobenzenamine

HRID 132408

反応式

HRID 132408 の反応式
[CH3:1][C:2]1[C:8]([N+:9]([O-:11])=[O:10])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].C(=O)([O-])O.[Na+].[I:17]Cl>CO>[I:17][C:7]1[CH:6]=[CH:5][C:3]([NH2:4])=[C:2]([CH3:1])[C:8]=1[N+:9]([O-:11])=[O:10]

参加物

5

反応物 3

HCID 117832-Methyl-3-nitroanilineHCID 24640Iodine chlorideHCID 516892Sodium Bicarbonate

生成物 1

HCID 597319804-Iodo-2-methyl-3-nitrobenzenamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a well stirred solution of 2-methyl-3-nitroaniline (10 g, 66 mmol) in methanol (150 mL) was added sodium hydrogencarbonate (264 mmol) followed by 1.0 M solution of iodine monochloride (72 mmol) at room temperature. After stirring for 1 h, the solvent was removed, diluted with ether, washed with 10% aqueous sodium thiosulfate solution. The solvent was removed and the crude iodide was in the next step.

後処理

  1. customthe solvent was removed
  2. additiondiluted with ether
  3. washwashed with 10% aqueous sodium thiosulfate solution
  4. customThe solvent was removed

出典と根拠

ORDレコード
ord-2bc134c838a349289d9037fc279b9ce1
出典データセット
uspto-grants-2008_06
特許番号
US07384931B2

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