Pyridine → HCID 178432494、化合物
反応式
[C:1]([O:4]C(=O)C)(=O)[CH3:2].[C:8]([C:10]1[CH:38]=[CH:37][CH:36]=[CH:35][C:11]=1[O:12][C:13]1[C:27]([O:28][C:29]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)=[CH:26][C:16]2[NH:17][C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=3)=[N:19][C:15]=2[CH:14]=1)#[N:9].[N:39]1C=CC=CC=1>>[N:31]1[CH:32]=[CH:33][CH:34]=[C:29]([O:28][C:27]2[C:13]([O:12][C:11]3[CH:35]=[CH:36][CH:37]=[CH:38][C:10]=3[C:8]3[N:39]=[C:1]([CH3:2])[O:4][N:9]=3)=[CH:14][C:15]3[NH:19][C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=4)=[N:17][C:16]=3[CH:26]=2)[CH:30]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
0.3 ml of acetic anhydride was added to a pyridine (0.5 ml) solution of 20 mg of 5-(2-(N-hydroxycarbaminidoyl)-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole obtained in the same manner as in Example 61 but using 5-(2-cyano-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole obtained in Example 5, and the reaction liquid was stirred overnight at 60° C. The solvent was evaporated away under reduced pressure, and this was purified through partitioning thin-layer chromatography (Kieselgel™ 60F254, Art 5744 (by Merck), chloroform/methanol=10/1) to obtain the entitled compound as a pale yellow solid.