Nitric Acid → 4,5-Difluoro-2-nitrophenol

HRID 132598ノート

反応式

HRID 132598 の反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].[N+:10]([O-])([OH:12])=[O:11]>C(O)(=O)C>[F:8][C:7]1[C:2]([F:1])=[CH:3][C:4]([OH:9])=[C:5]([N+:10]([O-:12])=[O:11])[CH:6]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 759273,4-Difluorophenol

生成物 1

HCID 27741824,5-Difluoro-2-nitrophenol

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

3,4-Difluorophenol (3.10 g, 23.7 mmole) was dissolved in acetic acid (15 ml). To the stirred solution was added dropwise a solution of fuming nitric acid (HNO3) (1.25 g, 29.7 mmole) in acetic acid (6 ml). The temperature was kept under 50° C. during the entire addition. After completed addition, the mixture was stirred for another hour. The reaction mixture was poured onto ice-water, giving precipitation of a yellowish solid.

後処理

  1. additionThe temperature was kept under 50° C. during the entire addition
  2. additionaddition
  3. additionThe reaction mixture was poured onto ice-water
  4. customgiving
  5. customprecipitation of a yellowish solid

出典と根拠

ORDレコード
ord-a2bd90cd85714b2fb5a9d68306852a5b
出典データセット
uspto-grants-2008_06
特許番号
US07388020B2

反応ノート

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