Sodium Hydroxide → HCID 23145661、化合物

HRID 13264ノート

反応式

HRID 13264 の反応式
[OH-].[Na+].[C:3]([N:6]1[CH2:10][CH2:9][CH2:8][CH:7]1[C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:14]([O:16]CC)=[O:15])(=[O:5])[CH3:4]>C(O)C>[C:3]([N:6]1[CH2:10][CH2:9][CH2:8][CH:7]1[C:11]1[CH:12]=[C:13]([CH:19]=[CH:20][C:21]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:14]([OH:16])=[O:15])(=[O:5])[CH3:4]

参加物

4

反応物 2

HCID 14798Sodium Hydroxide2 回HCID 23145505Ethyl 3-(1-acetyl-pyrrolidin-2-yl)-4-benzyloxybenzoate

生成物 1

HCID 23145661HCID 23145661、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

23 ml of aqueous 4 N sodium hydroxide solution was added to an ethanol (200 ml) solution of 18.7 g of ethyl 3-(1-acetyl-pyrrolidin-2-yl)-4-benzyloxybenzoate, and the reaction liquid was stirred overnight at room temperature. 15 ml of aqueous 4 N sodium hydroxide solution was added to the reaction liquid, and the reaction liquid was stirred for 7 hours. The reaction solvent was evaporated away under reduced pressure, and the resulting residue was diluted with water, and washed with ether. The aqueous layer was acidified with 6 N hydrochloric acid added thereto, then extracted with chloroform, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound as a white solid.

後処理

  1. customthe reaction liquid
  2. customthe reaction liquid
  3. stirringwas stirred for 7 hours
  4. customThe reaction solvent was evaporated away under reduced pressure
  5. additionthe resulting residue was diluted with water
  6. washwashed with ether
  7. additionadded
  8. extractionextracted with chloroform
  9. dry with materialdried with anhydrous magnesium sulfate
  10. customThe solvent was evaporated away under reduced pressure

出典と根拠

ORDレコード
ord-ac1fe18f368b4f6eb81e87d8e5fb4747
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

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