Di-tert-butyl dicarbonate → Tert-Butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamate

HRID 132803ノート

反応式

HRID 132803 の反応式
[NH2:1][CH2:2][C@@H:3]([C@H:5]1[CH2:9][O:8][C:7]([CH3:11])([CH3:10])[O:6]1)[OH:4].[O:12](C(OC(C)(C)C)=O)[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=O>C1COCC1>[CH3:10][C:7]1([CH3:11])[O:6][C@@H:5]([C@@H:3]([OH:4])[CH2:2][NH:1][C:13](=[O:12])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:9][O:8]1

参加物

4

反応物 2

HCID 90495Di-tert-butyl dicarbonateHCID 59734745(1S)-2-amino-1-[(4r)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

生成物 1

HCID 14249481Tert-Butyl (2S)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylcarbamate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Aminoalcohol 23 was dissolved in THF and BOC2O was added and stirred for several hrs. The solvent was removed and the product purified using silica gel chromatography.

後処理

  1. customThe solvent was removed
  2. customthe product purified

出典と根拠

ORDレコード
ord-6dacd23111d34dacac13d12d18d78972
出典データセット
uspto-grants-2008_06
特許番号
US07388118B2

反応ノート

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