反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)=[O:12])=[CH:5]2.[CH:19]12[CH2:24][CH:23]1[CH2:22][N:21]([CH2:25][CH2:26][CH2:27]O)[CH2:20]2>>[CH:19]12[CH2:24][CH:23]1[CH2:22][N:21]([CH2:25][CH2:26][CH2:27][O:1][C:2]1[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1)=[O:12])=[CH:5]3)[CH2:20]2参加物
3
実験手順
In analogy to the procedure described for the synthesis of example 1, step 1, the title compound was synthesized from (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone (example 5, step 3) and 3-(3-aza-bicyclo[3.1.0]hex-3-yl)-propan-1-ol (example 5, step 2). The title product was obtained in 49% yield as white solid. MS (m/e): 370.5 (MH+, 100%).
後処理
- customIn analogy to the procedure described for the synthesis of example 1, step 1
出典と根拠
- ORDレコード
- ord-3e3303021aa14bd39e263710560930e2
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07388095B2
関連ノート
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