1-Chloroethyl chloroformate → 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

HRID 132846

反応式

HRID 132846 の反応式
C([N:8]1[CH2:17][CH2:16][C:15]2[N:14]=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=[CH:11][C:10]=2[CH2:9]1)C1C=CC=CC=1.[Cl:22]C(OC(Cl)C)=O>CCOCC>[ClH:22].[F:21][C:18]([F:19])([F:20])[C:13]1[CH:12]=[CH:11][C:10]2[CH2:9][NH:8][CH2:17][CH2:16][C:15]=2[N:14]=1

参加物

4

反応物 2

HCID 5213051-Chloroethyl chloroformateHCID 577709166-Benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

生成物 1

HCID 574452562-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Treatment of the intermediate from Step A above with 1-chloroethyl chloroformate as described for Intermediate 20, Step C afforded the crude title compound. Trituration with ether provided the title compound as a pale orange powder. LC/MS 203.1 (M+1).

後処理

  1. customafforded the crude title compound

出典と根拠

ORDレコード
ord-49ee30c457a2404fb1fa107faf5b6def
出典データセット
uspto-grants-2008_06
特許番号
US07388019B2

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