化工社化工社 化学情報印刷レポート · 研究参考用
1-Chloroethyl chloroformate → 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloroethyl chloroformate | HCID 521305 | — |
| 反応物 | 6-Benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine | HCID 57770916 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride | HCID 57445256 | — |
反応手順
Treatment of the intermediate from Step A above with 1-chloroethyl chloroformate as described for Intermediate 20, Step C afforded the crude title compound. Trituration with ether provided the title compound as a pale orange powder. LC/MS 203.1 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07388019B2 |
| 出典データセット | uspto-grants-2008_06 |
| ORD ID | ord-49ee30c457a2404fb1fa107faf5b6def |
| 出典メモ | uspto-grants-2008_06 |