Trifluoroacetic acid → 2-(trifluoromethyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine

HRID 132862

反応式

HRID 132862 の反応式
C(OC([N:8]1[CH2:21][CH2:20][C:11]2[N:12]=[C:13]([C:16]([F:19])([F:18])[F:17])[N:14]=[CH:15][C:10]=2[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[F:19][C:16]([F:17])([F:18])[C:13]1[N:14]=[CH:15][C:10]2[CH2:9][NH:8][CH2:21][CH2:20][C:11]=2[N:12]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 692237216-(tert-Butoxycarbonyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

生成物 1

HCID 534714832-(trifluoromethyl)-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Reaction of the product from Step A above with trifluoroacetic acid in dichloromethane according to the procedure outlined for Intermediate 28, Step C afforded the title compound as a white powder. LC/MS 204.0 (M+1).

出典と根拠

ORDレコード
ord-cc45c23990ba456899627ba7fa8afba1
出典データセット
uspto-grants-2008_06
特許番号
US07388019B2

関連ノート

読み込み中…