Potassium Carbonate → 5-(2-Cyano-phenoxy)-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine

HRID 13292

反応式

HRID 13292 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].CN1CCCC1=O.F[C:24]1[C:25]([O:34][C:35]2[CH:36]=[N:37][C:38]([S:41]([CH3:44])(=[O:43])=[O:42])=[CH:39][CH:40]=2)=[CH:26][C:27]([N+:31]([O-:33])=[O:32])=[C:28]([NH2:30])[CH:29]=1>O>[C:4]([C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[O:1][C:24]1[C:25]([O:34][C:35]2[CH:36]=[N:37][C:38]([S:41]([CH3:44])(=[O:42])=[O:43])=[CH:39][CH:40]=2)=[CH:26][C:27]([N+:31]([O-:33])=[O:32])=[C:28]([NH2:30])[CH:29]=1)#[N:5]

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 119072-HydroxybenzonitrileHCID 13387N-methyl-2-pyrrolidoneHCID 231453335-Fluoro-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine

生成物 1

HCID 231457765-(2-Cyano-phenoxy)-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

60 mg of 2-hydroxy-benzonitrile and 70 mg of potassium carbonate were added to an N-methylpyrrolidinone (2 ml) solution of 150 mg of 5-fluoro-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine obtained in (step 3), and the reaction liquid was stirred at 90° C. for 5 hours. Water was added to the reaction liquid, and the deposit was taken out through filtration to obtain the entitled compound.

後処理

  1. customobtained in (step 3)
  2. customthe reaction liquid
  3. filtrationthe deposit was taken out through filtration
  4. customto obtain the entitled compound

出典と根拠

ORDレコード
ord-2db017ca3f4142d080bb5cc0e86c3cf0
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

関連ノート

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