Lithium Hydroxide → (S)-2-((S)-3-acetamido-3-((R)-sec-butyl)-2-oxopyrrolidin-1-yl)-N-((1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((2R,4S)-4-phenoxypyrrolidin-2-yl)propan-2-yl)-4-phenylbutanamide
反応式
[NH2:1][C@@H:2]([CH2:30][C:31]1[CH:36]=[C:35]([F:37])[CH:34]=[C:33]([F:38])[CH:32]=1)[C@@H:3]([C@H:5]1[CH2:9][C@H:8]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:7][N:6]1C(C1C=CC=CC=1)C1C=CC=CC=1)[OH:4].[C:39]([NH:42][C@:43]1([C@@H:92]([CH2:94][CH3:95])[CH3:93])[CH2:47][CH2:46][N:45]([C@@H:48]([CH2:83][CH2:84][C:85]2[CH:90]=[CH:89][CH:88]=[CH:87][CH:86]=2)[C:49](N[C@@H](CC2C=C(F)C=C(F)C=2)[C@@H]([C@H]2CCCCN2C(C2C=CC=CC=2)C2C=CC=CC=2)O)=[O:50])[C:44]1=[O:91])(=[O:41])[CH3:40].[Li+].[OH-].CO.C(Cl)(Cl)Cl>CCO.O>[C:39]([NH:42][C@:43]1([C@@H:92]([CH2:94][CH3:95])[CH3:93])[CH2:47][CH2:46][N:45]([C@@H:48]([CH2:83][CH2:84][C:85]2[CH:86]=[CH:87][CH:88]=[CH:89][CH:90]=2)[C:49]([NH:1][C@@H:2]([CH2:30][C:31]2[CH:36]=[C:35]([F:37])[CH:34]=[C:33]([F:38])[CH:32]=2)[C@H:3]([OH:4])[C@H:5]2[CH2:9][C@H:8]([O:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:7][NH:6]2)=[O:50])[C:44]1=[O:91])(=[O:41])[CH3:40]参加物
7
反応物 4
HCID 3939Lithium Hydroxide
HCID 21584188Chloroform methanol
HCID 69194179(S)-2-((S)-3-acetamido-3-((R)-sec-butyl)-2-oxopyrrolidin-1-yl)-N-((1S,2S)-1-((R)-1-benzhydrylpiperidin-2-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-4-phenylbutanamide
HCID 69195486(1S,2S)-2-amino-1-((2R,4S)-1-benzhydryl-4-phenoxypyrrolidin-2-yl)-3-(3,5-difluorophenyl)propan-1-ol生成物 1
