Hydrazine hydrate (1:1) → HCID 10149166、化合物
反応式
I[C:2]1[C:7]2[C:8](=O)[C:9]3[CH:16]=[CH:15][CH:14]=[C:13]([NH:17]C(=O)OCC4C=CC=CC=4)[C:10]=3[CH2:11][CH2:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.O.[NH2:30][NH2:31]>>[N:30]1[NH:31][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[CH2:12][CH2:11][C:10]4=[C:13]([NH2:17])[CH:14]=[CH:15][CH:16]=[C:9]4[C:8]=1[C:7]=23参加物
3
実験手順
50 mg of benzyl N-(6-iodo-5-oxo-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-1-yl)carbamate prepared in Example 8-a was treated with hydrazine monohydrate by the procedure of Example 1-h and purified and separated by silica gel column chromatography (ethyl acetate:hexane=1:2), to give 15 mg of the title compound as a colorless powder.
後処理
- custompurified
- customseparated by silica gel column chromatography (ethyl acetate:hexane=1:2)
出典と根拠
- ORDレコード
- ord-07156b2ce8cf4e15bc6cb4a3013953af
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07390797B2
反応ノート
読み込み中…