Hydrochloric Acid → HCID 178514823、化合物
反応式
C([Mg]Cl)(C)C.Br[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1.C([O:17][B:18]([CH:24]=[CH2:25])OCCCC)CCC.Cl>C1COCC1.O>[N:9]1[CH:10]=[CH:11][CH:12]=[C:7]([CH:25]=[CH:24][BH:18][OH:17])[CH:8]=1参加物
7
実験手順
Isopropylmagnesium chloride (2.0 M in THF) (5.0 mL, 10 mmol) was added to a solution of 3-bromopyridine (1.60 g, 10.0 mmol) in THF (15 mL) under nitrogen atmosphere at room temperature and the mixture was stirred for 1 h. Vinylboronic acid dibutyl ester (3.4 mL) was added to the reaction dropwise and the mixture was stirred at room temperature for 18 h. Water was added and the pH was adjusted to 7 with 1 M hydrochloric acid. The mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound (1.04 g, 78%).
後処理
- stirringthe mixture was stirred at room temperature for 18 h
- extractionThe mixture was extracted with ethyl acetate
- washThe organic layer was washed with brine
- dry with materialdried on anhydrous sodium sulfate
- customThe solvent was removed under reduced pressure
出典と根拠
- ORDレコード
- ord-f6c3229880604ca08b2c20172511e4fc
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07390806B2
反応ノート
読み込み中…