2-Amino-3-nitro-8-methylquinoline → 2,3-Diamino-8-methylquinoline
反応式
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][C:9]2[C:4](=[C:5]([CH3:15])[CH:6]=[CH:7][CH:8]=2)[N:3]=1>CO.O1CCCC1.[Pd]>[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][C:9]2[C:4](=[C:5]([CH3:15])[CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
4
実験手順
0.4 g of palladium on active carbon (5% Pd) is added to a solution of 1.1 g of 2-amino-3-nitro-8-methylquinoline (compound B1) in 50 ml of methanol/tetrahydrofurane 1:1 and the resulting suspension is hydrated for 1 h. The catalyst is filtered off and the filtrate is evaporated in vacuo. The residue is chromatographed on silica gel using dichloromethane/methanol 10:1 to give 0.79 g of the title compound as colourless solid.
後処理
- filtrationThe catalyst is filtered off
- customthe filtrate is evaporated in vacuo
- customThe residue is chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-36d47d233a1c43da84c954c914752c10
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07390819B2
反応ノート
読み込み中…