Methyl 3-(4-methoxypyridin-2-yl)acrylate → Methyl 3-(4-methoxypyridin-2-yl)propanoate
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([CH:9]=[CH:10][C:11]([O:13][CH3:14])=[O:12])[CH:4]=1>CO.[Pd]>[CH3:14][O:13][C:11](=[O:12])[CH2:10][CH2:9][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][N:6]=1参加物
4
実験手順
43.1 g of methyl 3-(4-methoxypyridin-2-yl)acrylate (starting material F3) in 600 ml of methanol are hydrogenated over 3.0 g of Pd/C (10%) until the starling material has disappeared (TLC). The catalyst is filtered off, and the mixture is then concentrated and dried under high vacuum. This gives 41.95 g of the title compound as a light-yellow oil. The mass spectrum shows the molecular peak MH+ at 196 Da.
後処理
- filtrationThe catalyst is filtered off
- concentrationthe mixture is then concentrated
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-f8fd19aaf7734f66bab7e37a377e38a2
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07390819B2
反応ノート
読み込み中…