Hydrochloric Acid → Ethyl 2-(3,5-difluorophenyl)-3-hydroxy-2-propenoate

HRID 133180ノート

反応式

HRID 133180 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[H-].[Na+].Cl.[CH:18](OCC)=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:18][OH:19])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 11481060Ethyl 2-(3,5-difluorophenyl)acetate

生成物 1

HCID 67388060Ethyl 2-(3,5-difluorophenyl)-3-hydroxy-2-propenoate

実験手順

5.0 g of ethyl 3,5-difluorophenylacetate are dissolved in 50 ml of ethyl formate. 2.0 g of 60% NaH are added portionwise. The mixture is poured onto a 1N HCl solution and then extraction is carried out with AcOEt. The residue is triturated in petroleum ether, the remaining white precipitate is filtered off and then the filtrate is evaporated to produce 3.3 g of the expected compound in the form of a liquid.

後処理

  1. extractionextraction
  2. customThe residue is triturated in petroleum ether
  3. filtrationthe remaining white precipitate is filtered off
  4. customthe filtrate is evaporated

出典と根拠

ORDレコード
ord-dab81ae7a179419f995200fdce64b5a8
出典データセット
uspto-grants-2008_06
特許番号
US07390818B2

反応ノート

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