Methanol → Methyl 3-Hydroxyphenylacetate
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:12]O>S(=O)(=O)(O)O>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
10 g of 3-hydroxyphenylacetic acid are dissolved in 60 ml of methanol and 2.5 ml of sulphuric acid. The solution is heated at reflux for two hours. It is brought back to ambient temperature and the methanol is evaporated. The residue is taken up in a saturated K2CO3 solution. Extraction is carried out with AcOEt. The organic phase is dried over MgSO4, filtered and evaporated to dryness. 11.1 g of oil are obtained.
後処理
- temperatureThe solution is heated
- temperatureat reflux for two hours
- customis brought back to ambient temperature
- customthe methanol is evaporated
- extractionExtraction
- dry with materialThe organic phase is dried over MgSO4
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-7422c6e426094c6b92808842d39c97dd
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07390818B2
反応ノート
読み込み中…