Methanol → Methyl 3-Hydroxyphenylacetate

HRID 133185

反応式

HRID 133185 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:12]O>S(=O)(=O)(O)O>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 887MethanolHCID 121223'-Hydroxyphenylacetic acid

生成物 1

HCID 39129Methyl 3-Hydroxyphenylacetate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

10 g of 3-hydroxyphenylacetic acid are dissolved in 60 ml of methanol and 2.5 ml of sulphuric acid. The solution is heated at reflux for two hours. It is brought back to ambient temperature and the methanol is evaporated. The residue is taken up in a saturated K2CO3 solution. Extraction is carried out with AcOEt. The organic phase is dried over MgSO4, filtered and evaporated to dryness. 11.1 g of oil are obtained.

後処理

  1. temperatureThe solution is heated
  2. temperatureat reflux for two hours
  3. customis brought back to ambient temperature
  4. customthe methanol is evaporated
  5. extractionExtraction
  6. dry with materialThe organic phase is dried over MgSO4
  7. filtrationfiltered
  8. customevaporated to dryness

出典と根拠

ORDレコード
ord-7422c6e426094c6b92808842d39c97dd
出典データセット
uspto-grants-2008_06
特許番号
US07390818B2

関連ノート

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