3-Benzoylbenzoic acid → 3-Benzylbenzoic acid

HRID 133209

反応式

HRID 133209 の反応式
[C:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.OS(O)(=O)=O.CCCCCC.[Pd]>[CH2:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 1

HCID 1013863-Benzoylbenzoic acid

生成物 1

HCID 41245533-Benzylbenzoic acid

試薬・触媒・溶媒 4

HCID 23938Palladium触媒HCID 1118Sulfuric Acid溶媒HCID 8058Hexane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a Parr bottle containing 3-benzoylbenzoic acid (0.044 moles) (Aldrich) in 150 mL of ethyl acetate and 4.5 mL of concentrated H2SO4 was added 10 grams of 5% Pd/C. The mixture was hydrogenated on a Parr apparatus under hydrogen (45 psi) overnight. The reaction mixture was then filtered through Hyflo, washing with ethyl acetate. The filterate was dried over Na2SO4, filtered and concentrated to give an oil. The oil was slurried in hexane and the resulting white solid was collected by filtration to afford 3-benzylbenzoic acid, which was used without further purification.

後処理

  1. filtrationThe reaction mixture was then filtered through Hyflo
  2. washwashing with ethyl acetate
  3. dry with materialThe filterate was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customto give an oil
  7. filtrationthe resulting white solid was collected by filtration

出典と根拠

ORDレコード
ord-fda428b186d144ffa75ae62ff07f4ccb
出典データセット
uspto-grants-2008_06
特許番号
US07390801B2

関連ノート

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