Hydrazine hydrate (1:1) → 3-Fluoro-4-phenylmethoxyaniline

HRID 13323ノート

反応式

HRID 13323 の反応式
O.NN.[CH2:4]([O:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][C:13]=1[F:21])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>[Ni].CO>[CH2:4]([O:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][C:13]=1[F:21])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 220309121-(Benzyloxy)-2-fluoro-4-nitrobenzene

生成物 1

HCID 219518923-Fluoro-4-phenylmethoxyaniline

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

2.91 ml of hydrazine monohydrate and about 1 g of developed Raney nickel catalyst were added to a methanol (60 ml) solution of 4.94 g of 4-benzyloxy-3-fluoronitrobenzene, and the reaction liquid was stirred at room temperature for 2 hours. The catalyst was removed through filtration through Celite, and the solvent was evaporated away under reduced pressure to obtain the entitled compound as a yellow oily substance.

後処理

  1. customthe reaction liquid
  2. customThe catalyst was removed through filtration through Celite
  3. customthe solvent was evaporated away under reduced pressure
  4. customto obtain the entitled compound as a yellow oily substance

出典と根拠

ORDレコード
ord-8a7b2fe512ff448ba96e29c11a108f22
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

反応ノート

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