Pyridine → Isobutyl 2-bromopropionate

HRID 133308

反応式

HRID 133308 の反応式
[CH2:1]([OH:5])[CH:2]([CH3:4])[CH3:3].N1C=CC=CC=1.[Br:12][CH:13]([CH3:17])[C:14](Br)=[O:15]>C(OCC)C>[Br:12][CH:13]([CH3:17])[C:14]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:15]

参加物

5

反応物 3

HCID 1049PyridineHCID 6560IsobutanolHCID 79047Propanoyl bromide, 2-bromo-

生成物 1

HCID 522337Isobutyl 2-bromopropionate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.

後処理

  1. washwashed with 1N HCl, water, aqueous NaHCO3, brine
  2. dry with materialdried over magnesium sulfate or sodium sulfate
  3. customRemoval of the solvents at reduced pressure

出典と根拠

ORDレコード
ord-bf0296674c8a4d2b99889b4a6245a2a7
出典データセット
uspto-grants-2008_06
特許番号
US07390801B2

関連ノート

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