Methyl pyruvate → N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester

HRID 133340

反応式

HRID 133340 の反応式
C1O[C:9]2C=CC(N)=[CH:4][C:3]=2O1.C(OC)(=O)C(C)=O.[CH3:18][O:19][C:20](=[O:33])[C@H:21]([CH3:32])[NH:22][C:23]1[CH:28]=[CH:27][C:26]2[O:29][CH2:30][O:31][C:25]=2[CH:24]=1>C(O)C(C)C>[CH2:18]([O:19][C:20](=[O:33])[C@H:21]([CH3:32])[NH:22][C:23]1[CH:28]=[CH:27][C:26]2[O:29][CH2:30][O:31][C:25]=2[CH:24]=1)[CH:3]([CH3:4])[CH3:9]

参加物

5

反応物 3

HCID 11748Methyl pyruvateHCID 843101,3-Benzodioxol-5-amineHCID 54531586N-(3,4-methylenedioxyphenyl)alanine methyl ester

生成物 1

HCID 54134455N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester

試薬・触媒・溶媒 1

HCID 6560Isobutanol溶媒

実験手順

Following reductive amination General Procedure AA above and using 3,4-methylenedioxyaniline (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-methylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above and using iso butanol to provide the title compound as an oil. The reaction was monitored by silica gel dc (Rf=0.61 in 25% EtOAc/hexanes). Purification was by preparative plate chromatography with silica gel using 25% EtOAc/hexanes as the eluant.

後処理

  1. customwas prepared

出典と根拠

ORDレコード
ord-12e04e799171427d96503c1f1f1c2440
出典データセット
uspto-grants-2008_06
特許番号
US07390801B2

関連ノート

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