L-Alanine → N-[(2-naphthyl)acetyl]-L-alanine Iso-butyl Ester

HRID 133358

反応式

HRID 133358 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12]([OH:14])=O.[NH2:15][C@H:16]([C:18]([OH:20])=[O:19])[CH3:17]>>[CH2:1]([O:19][C:18](=[O:20])[C@H:16]([CH3:17])[NH:15][C:12](=[O:14])[CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[CH:2]([CH3:11])[CH3:3]

参加物

3

反応物 2

HCID 5950L-AlanineHCID 113932-Naphthaleneacetic acid

生成物 1

HCID 15481768N-[(2-naphthyl)acetyl]-L-alanine Iso-butyl Ester

実験手順

Following General Procedure BB and using 2-naphthylacetic acid (Aldrich) and L-alanine is iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 128°-129° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

後処理

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. extractionwas by extraction with Et2O

出典と根拠

ORDレコード
ord-b6ffa61a8c7b4a9cb5f26d2206c05357
出典データセット
uspto-grants-2008_06
特許番号
US07390801B2

関連ノート

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