Sodium Hydroxide → (2-Amino-5-phenyl-thiophen-3-yl)-phenyl-methanone

反応式

[C:1]([C:9]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[S:11][C:10]=1[NH:20]C(=O)C)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[NH4+].[Cl-]>CCO>[NH2:20][C:10]1[S:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:13][C:9]=1[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:8]

参加物

実験手順

To a stirred solution of 0.393 g (1.22 mmol) of N-(3-benzoyl-5-phenyl-thiophen-2-yl)-acetamide in 15 ml EtOH was added 2.5 ml of aq. NaOH (4N). The reaction mixture stirred at RT for 1 hour, and then poured onto an aq. solution of NH4Cl sat. and the product was extracted with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated in vacuo to yield 0.45 g (98%) of (2-amino-5-phenyl-thiophen-3-yl)-phenyl-methanone as a light brown solid. ES-MS m/e (%): 280 (M+H+, 100).