2-Fluorophenol → 5-(2-Fluoro-phenoxy)-2-pyridin-2-yl-6-(4-methanesulfonyl-phenoxy)-1H-benzimidazole

HRID 13372

反応式

HRID 13372 の反応式
C(OC([C:6]1[CH:38]=[CH:37][CH:36]=[CH:35][C:7]=1[O:8][C:9]1[C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:22][C:12]2[NH:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[N:15][C:11]=2[CH:10]=1)=O)C.[F:39]C1C=CC=CC=1O>>[F:39][C:6]1[CH:38]=[CH:37][CH:36]=[CH:35][C:7]=1[O:8][C:9]1[C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:22][C:12]2[NH:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[N:15][C:11]=2[CH:10]=1

参加物

3

反応物 2

HCID 97072-FluorophenolHCID 231451405-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole

生成物 1

HCID 231455405-(2-Fluoro-phenoxy)-2-pyridin-2-yl-6-(4-methanesulfonyl-phenoxy)-1H-benzimidazole

実験手順

The entitled compound was obtained as a colorless solid in the same method as in Example 196 (step 4) to (step 6) or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14 and 2-fluorophenol.

後処理

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 196 (step 4) to (step 6) or in accordance with the method

出典と根拠

ORDレコード
ord-3cf2e11f49db4a2eb9c671ea18a3af36
出典データセット
uspto-grants-2010_06
特許番号
US07728025B2

関連ノート

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