4-Bromoaniline → N-(4-bromophenyl)-5-methoxy-1,3-benzothiazol-2-amine
反応式
Br[C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=2[N:6]=1.[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1>CN1C(=O)CCC1>[Br:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:2]2[S:3][C:4]3[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:5]=3[N:6]=2)=[CH:16][CH:15]=1参加物
4
実験手順
The mixture containing 2-bromo-5-methoxybenzthiazole (1 eq), 4-Bromoaniline (2 eq) and disopropylethylamine was subjected to microwave in NMP at 220° C. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave the desired product. MS: MH+=335
後処理
- concentrationThe resultant mixture was concentrated
- custompartitioned between ethyl acetate and water
- washThe organic layer was washed with brine
- customdried
- customPurification on silica gel
出典と根拠
- ORDレコード
- ord-02426daa880b45148c58ba484bdb01f2
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728010B2
反応ノート
読み込み中…