Water → [1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

HRID 1348564

反応式

HRID 1348564 の反応式
[CH3:1][N:2]([CH3:18])[CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.[C:19](C1NC=CN=1)(C1NC=CN=1)=[S:20].O>CN(C=O)C>[N:15]([C:12]1[CH:13]=[CH:14][C:9]([N:6]2[CH2:7][CH2:8][CH:3]([N:2]([CH3:18])[CH3:1])[CH2:4][CH2:5]2)=[CH:10][CH:11]=1)=[C:19]=[S:20]

参加物

5

反応物 3

HCID 962WaterHCID 11086151N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amineHCID 11412697Thiocarbonyl diimidazole

生成物 1

HCID 21091577[1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine (Example 2, 1.1 g, 5.0 mmol) was dissolved in DMF (5 mL). To the stirred solution, thiocarbonyl diimidazole (Aldrich, 1.18 g, 90%, 6 mmol) was added and the solution was stirred at room temperature for 80 minutes. The mixture was poured into water and extracted with diethyl ether. The extract was dried with sodium sulfate and concentrated to give a pale yellow solid. 1.12 g, 85%. MS (m+H)+: 262.

後処理

  1. extractionextracted with diethyl ether
  2. dry with materialThe extract was dried with sodium sulfate
  3. concentrationconcentrated
  4. customto give a pale yellow solid

出典と根拠

ORDレコード
ord-96af6633f0ff44f3afb9eaf504ffa333
出典データセット
uspto-grants-2007_05
特許番号
US07211576B2

関連ノート

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