(-)-(6R,7S)-6-cyclopropyl-7-dibenzylamino-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one → (6R,7S)-7-Amino-6-cyclopropyl-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one

反応式

[CH:1]1([C@@H:4]2[C@H:10]([N:11](CC3C=CC=CC=3)CC3C=CC=CC=3)[C:9](=[O:26])[NH:8][C:7]3[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:6]=3[O:5]2)[CH2:3][CH2:2]1>CO.[Pd]>[NH2:11][C@@H:10]1[C:9](=[O:26])[NH:8][C:7]2[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:6]=2[O:5][C@@H:4]1[CH:1]1[CH2:3][CH2:2]1

参加物

実験手順

The title compound was prepared by hydrogenation of (−)-(6R,7S)-6-cyclopropyl-7-dibenzylamino-2-fluoro-6,7-dihydro-9H-5-oxa-9-aza-benzocyclohepten-8-one in methanol with Pd/C (10%), MS m/e (%): 235.1 (M+H+, 100).