Methyl iodide → Benzoic Acid

HRID 13491

反応式

HRID 13491 の反応式
CNC=O.N([C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([OH:13])=[O:12])=C=S.IC>CO>[C:11]([OH:13])(=[O:12])[C:10]1[CH:14]=[CH:15][CH:16]=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 31254N-MethylformamideHCID 75046Benzoic acid, 3-isothiocyanato-

生成物 1

HCID 243Benzoic Acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

To 4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 3-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h and concentrated the solvent and purified on silica gel to yield 3-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.

後処理

  1. concentrationconcentrated the solvent
  2. custompurified on silica gel

出典と根拠

ORDレコード
ord-bf3d1cacbe2b4322bcf5fee1703039c8
出典データセット
uspto-grants-2010_06
特許番号
US07728010B2

関連ノート

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