2-Bromobenzoyl chloride → (2-Bromophenyl)(4-methylpiperazin-1-yl)methanone

HRID 1350043ノート

反応式

HRID 1350043 の反応式
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:15]1[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]1)=[O:5]

参加物

4

反応物 2

HCID 235422-Bromobenzoyl chlorideHCID 531671-Methylpiperazine

生成物 1

HCID 668767(2-Bromophenyl)(4-methylpiperazin-1-yl)methanone収率 78.5%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of 2-bromobenzoyl chloride (2 g, 9 mmol) in toluene (30 mL) was added N-methylpiperazine (2 mL, 18 mmol, 2 equiv.). The resulting mixture was stirred overnight. The precipitate was filtered and the filtrate was concentrated under reduced pressure. The residue was taken into dichloromethane, washed with water. The organic layer was concentrated under reduced pressure to give 2 g (77% yield) of intermediate 10.

後処理

  1. filtrationThe precipitate was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. washwashed with water
  4. concentrationThe organic layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a0aff40fd8cd48d497cc85e959dfde82
出典データセット
uspto-grants-2007_05
特許番号
US07214676B2

反応ノート

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