Hydrochloric Acid → Methyl 6-methoxy-1,2,3,4-tetrahydroisoquinoline-4-carboxylate hydrochloride

HRID 1350076ノート

反応式

HRID 1350076 の反応式
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[N:9][CH2:8][CH:7]2[C:14]([O:16][CH3:17])=[O:15].Cl>CO.CCOCC.[Pd]>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH2:10][NH:9][CH2:8][CH:7]2[C:14]([O:16][CH3:17])=[O:15]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 21094286HCID 21094286、化合物

生成物 1

HCID 21094284Methyl 6-methoxy-1,2,3,4-tetrahydroisoquinoline-4-carboxylate hydrochloride

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

The compound obtained in Step D (9.21g), in the form of a base, is dissolved in 150 ml of methanol and then palladium-on-carbon (900 mg) is added to the solution. The reaction mixture is stirred at ambient temperature under hydrogen for 4 hours. After removal of the palladium-on-carbon by filtration, the organic phase is evaporated under reduced pressure. The oil obtained is taken up in ether saturated with HCl. The precipitate formed is suction-filtered off and recrystallised from acetonitrile to yield the title product in the form of a white solid.

後処理

  1. customAfter removal of the palladium-on-carbon
  2. filtrationby filtration
  3. customthe organic phase is evaporated under reduced pressure
  4. customThe oil obtained
  5. customThe precipitate formed
  6. filtrationis suction-filtered off
  7. customrecrystallised from acetonitrile

出典と根拠

ORDレコード
ord-2314adbefcd24f89a8ba6b483ab38db5
出典データセット
uspto-grants-2007_05
特許番号
US07214689B2

反応ノート

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