1-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene → HCID 58646756、化合物

HRID 1350193ノート

反応式

HRID 1350193 の反応式
[C:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C:6]=1[NH:15]CC1C=CC=CC=1)([O:3][CH3:4])=[O:2]>CO.[Pd]>[C:1]([C@@H:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][C@@H:6]1[NH2:15])([O:3][CH3:4])=[O:2]

参加物

4

反応物 1

HCID 210946731-Carbomethoxy-2-benzylamino-3,4-dihydronaphthalene

生成物 1

HCID 58646756HCID 58646756、化合物収率 15.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a suspension of 1-carbomethoxy-2-benzylamino-3,4-dihydronaphthalene (1.46 g) in methanol (30 mL) at room temperature, was added 10% palladium on carbon (200 mg). The resulting mixture was shaken under a hydrogen atmosphere at 40 psi for 3 d using a Parr apparatus. The catalyst was filtered, and the filtrate was evaporated under vacuum to obtain crude product. The crude product was purified by reverse phase preparative HPLC to obtain predominantly cis 1-carbomethoxy-2-amino-1,2,3,4-tetrahydronaphthalene (160 mg) as a cis-trans mixture (10:1).

後処理

  1. filtrationThe catalyst was filtered
  2. customthe filtrate was evaporated under vacuum
  3. customto obtain crude product
  4. customThe crude product was purified by reverse phase preparative HPLC

出典と根拠

ORDレコード
ord-5df5577a07544c31ad34fcc1d73bbb91
出典データセット
uspto-grants-2007_05
特許番号
US07214704B2

反応ノート

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