Pyridoxine Hydrochloride → Pyridoxine

In a second alternative and preferred workup, the reaction mixture (following complete conversion to compound (C)) is cooled to 20° C. and diluted with water (approximately 2.80 L of water for every 1 kg of starting pyridoxine HCl). After phase separation the organic phase is washed with water. The combined aqueous phases are reextracted twice with TBME. The combined TBME phases are washed once with saturated NaHCO3-solution and once with diluted brine. The MTBE-product solution is concentrated to a concentration of about 50% and stored at room temperature until it is further converted. If this second alternative workup is used, the volume of MTBE in the synthetic step is preferably reduced by about 26%.

1. customAfter phase separation the organic phase
2. washis washed with water
3. washThe combined TBME phases are washed once with saturated NaHCO3-solution and once with diluted brine
4. concentrationThe MTBE-product solution is concentrated to a concentration of about 50%
5. customstored at room temperature until it

ORDレコード

ord-ffc973ba8df24903b7496f16c866375a

出典データセット

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07214799B2