N,N-dimethyl-5-nitropyridin-2-amine → N2,N2-dimethylpyridine-2,5-diamine

HRID 13507

反応式

HRID 13507 の反応式
[CH3:1][N:2]([CH3:12])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][N:4]=1>[Pd].C(O)C>[CH3:1][N:2]([CH3:12])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][N:4]=1

参加物

4

反応物 1

HCID 75707N,N-dimethyl-5-nitropyridin-2-amine

生成物 1

HCID 78642N2,N2-dimethylpyridine-2,5-diamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 2-(dimethylamino)-5-nitropyridine (1 eq) and 5% palladium on carbon (0.3 eq) in ethanol was stirred at room temperature and flushed with nitrogen. The reaction vessel was evacuated and purged with hydrogen three times. The reaction mixture was left under an atmosphere of hydrogen overnight. Nitrogen was flushed through the reaction and then the reaction was filtered through a celite pad. The celite pad was washed with excess ethanol before the solvent was removed by evaporation under reduced pressure to afford 2-(dimethylamino)-5-aminopyridine.

後処理

  1. customflushed with nitrogen
  2. customThe reaction vessel was evacuated
  3. custompurged with hydrogen three times
  4. customNitrogen was flushed through the reaction
  5. filtrationthe reaction was filtered through a celite pad
  6. washThe celite pad was washed with excess ethanol before the solvent
  7. customwas removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-b3951463aaae402abfa19be9984785d4
出典データセット
uspto-grants-2010_06
特許番号
US07728010B2

関連ノート

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