Trifluoroacetic acid → [3-Chloro-4-(trifluoromethyl)phenoxy]acetic acid
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[C:17]([F:20])([F:19])[F:18])[O:5][CH2:6][C:7]([O:9]C(C)(C)C)=[O:8].FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[C:17]([F:18])([F:19])[F:20])[O:5][CH2:6][C:7]([OH:9])=[O:8]参加物
3
実験手順
tert-Butyl [3-chloro-4-(trifluoromethyl)phenoxy]acetate (1.2 g, 3.8 mmol) was added trifluoroacetic acid (TFA) (3 ml). The mixture was stirred for 5 hours at ambient temperature. The solvent was removed under reduced pressure to give the residue, which was applied to a recrystallization from hexane-methylene dichloride to furnish 251 mg (80% yield) of the title compound as a brown solid.
後処理
- customThe solvent was removed under reduced pressure
- customto give the residue, which
- customwas applied to a recrystallization from hexane-methylene dichloride
出典と根拠
- ORDレコード
- ord-3354943425a34c6ea8199794d0bb8eb7
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07214824B2
反応ノート
読み込み中…