Trifluoroacetic acid → HCID 21097510、化合物
反応式
[CH3:1][C:2]1([CH3:21])[CH2:11][CH2:10][CH2:9][C:8]2[CH:7]=[C:6]([O:12][CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[CH:5]=[CH:4][C:3]1=2.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1([CH3:21])[CH2:11][CH2:10][CH2:9][C:8]2[CH:7]=[C:6]([O:12][CH2:13][C:14]([OH:16])=[O:15])[CH:5]=[CH:4][C:3]1=2参加物
4
反応条件
- 温度
- 0 °C
実験手順
A mixture of tert-butyl [(5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetate (2.8 g, 9.6 mmol), trifluoroacetic acid (10.0 ml) and methylene dichloride (20 ml) was stirred for 2 hours at 0° C. After being concentrated under reduced pressure, the crude residue was triturated using hexane and collected by filtration to give 1.45 g of the title compound as a white solid, which was used for further reaction without purification.