Chloric acid → 2-Chloro-1-(1,1-dimethylethyl)-4-nitrobenzene

HRID 1350837

反応式

HRID 1350837 の反応式
[Cl:1](O)(=O)=O.[C:5]([C:9]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:10]=1N)([CH3:8])([CH3:7])[CH3:6].N([O-])=O.[Na+]>[Cu](Cl)Cl.O>[C:5]([C:9]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:10]=1[Cl:1])([CH3:8])([CH3:7])[CH3:6]

参加物

6

反応物 3

HCID 19654Chloric acid2 回HCID 8261032-Tert-butyl-5-nitroanilineHCID 23668193Sodium Nitrite

生成物 1

HCID 210974512-Chloro-1-(1,1-dimethylethyl)-4-nitrobenzene収率 78%

試薬・触媒・溶媒 2

HCID 24014Cupric Chloride触媒HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

To a conc. chloric acid (10 ml) suspension of 2-tert-butyl-5-nitroaniline (WO 02055501) (1.94 g, 10.0 mmol) was added the H2O (5 ml) solution of sodium nitrite (690 mg, 10.0 mmol) at 0° C. The mixture was stirred at 0° C. for 20 min and to the mixture was then added the conc. chloric acid (10 ml) solution of copper chloride (900 mg, 10.0 mmol) at 70° C. The reaction mixture was stirred at 70° C. for 20 min and the resulting precipitate was collected by filtration, washed with H2O and dried under reduced pressure to furnish furnish 1.76 g (78% yield) of the title compound as a white solid.

後処理

  1. stirringThe reaction mixture was stirred at 70° C. for 20 min
  2. filtrationthe resulting precipitate was collected by filtration
  3. washwashed with H2O
  4. customdried under reduced pressure
  5. customto furnish

出典と根拠

ORDレコード
ord-65d542d641904b0f959c1f6aa2635400
出典データセット
uspto-grants-2007_05
特許番号
US07214824B2

関連ノート

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