Dimethylformamide → Dichlorobenzylidenamine

HRID 1350911

反応式

HRID 1350911 の反応式
Cl.[Cl:2]CCC(N)(C)C.[Cl:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14](Cl)[C:11]=1C=O.C[N:20]([CH3:23])C=O>C1(C)C=CC=CC=1.C(C(OC(CC)(CC)C)(CC)C)C.O1CCCC1.CS(C)=O.C(Cl)Cl>[Cl:9][C:10]1[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=1[C:23]([Cl:2])=[NH:20]

参加物

9

反応物 3

HCID 6228DimethylformamideHCID 67372,6-DichlorobenzaldehydeHCID 210945474-Chloro-2-methylbutan-2-amine hydrochloride

生成物 1

HCID 131726441Dichlorobenzylidenamine

試薬・触媒・溶媒 5

HCID 679Dimethyl Sulfoxide溶媒HCID 1140Toluene溶媒HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒HCID 12430074Diethylethylether溶媒

実験手順

The base is liberated from about 80–90, preferably 84.0 mmol of 3-chloro-1,1-dimethylpropylamine-hydrochloride by known methods. The free base is dissolved in about 50 mL of a solvent, preferably toluene, diethylethylether, tetrahydrofuran, dimethylsulphoxide, dimethylformamide or methylene chloride and about 60 to 100 mmol, preferably 80.0 mmol of 2,6-dichlorobenzaldehyde are added at ambient temperature, with stirring. The reaction mixture is stirred for 5 to 20 h, preferably for 15 h at ambient temperature, dried again and the solvent is removed. The corresponding dichlorobenzylidenamine of compound (III) is obtained.

後処理

  1. additionare added at ambient temperature
  2. stirringThe reaction mixture is stirred for 5 to 20 h, preferably for 15 h at ambient temperature
  3. customdried again
  4. customthe solvent is removed

出典と根拠

ORDレコード
ord-6af98bf814c24801a9689cef8d7e3e26
出典データセット
uspto-grants-2007_05
特許番号
US07214698B2

関連ノート

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