Water → HCID 22932162、化合物

反応式

[OH:1][CH2:2][CH2:3][NH:4][NH2:5].[CH3:6][CH:7]([CH3:21])[C:8](=O)[CH2:9][C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=S.C(N(CC)CC)C.O>C(#N)C>[CH2:13]([O:12][C:10]1[CH:9]=[C:8]([CH:7]([CH3:21])[CH3:6])[N:4]([CH2:3][CH2:2][OH:1])[N:5]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

実験手順

2-Hydroxyethylhydrazine (1.90 g) was added to a solution of O-Benzyl 4-methyl-3-oxothiopentanoate (5.90 g) and triethylamine (5.05 g) in acetonitrile (60 mL), and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into water, and the mixture was extracted with diethyl ether. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=1/1) to give the title compound (5.90 g).