Sodium borohydride → 2-(Benzyl-methyl-amino)-1-(4-fluorophenyl)-ethanol
反応式
[CH2:1]([N:8]([CH3:19])[CH2:9][C:10]([C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[CH2:1]([N:8]([CH3:19])[CH2:9][CH:10]([C:12]1[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=1)[OH:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
2-(Benzyl-methyl-amino)-1-(4-fluorophenyl)-ethanone (56.9 g) was dissolved in methanol (550 mL), and sodium borohydride was gradually added on an ice bath. After stirring at room temperature for 1 hour, the residue after evaporating methanol at reduced pressure was purified by NH silica gel column chromatography (hexane/ethyl acetate), and a yellow oily substance (54.6 g) was obtained.
後処理
- customthe residue after evaporating methanol at reduced pressure
- customwas purified by NH silica gel column chromatography (hexane/ethyl acetate)
- customa yellow oily substance (54.6 g) was obtained
出典と根拠
- ORDレコード
- ord-9bcd5aea5d734a1b8a2861894a84a128
- 出典データセット
- uspto-grants-2007_05
- 特許番号
- US07217723B2
反応ノート
読み込み中…